Table 4 Voxelwise temporal changes in tumour DCE-MRI derived microvascular parameters.

From: Detection of early changes in the post-radiosurgery vestibular schwannoma microenvironment using multinuclear MRI

Patient

Voxelwise Δve (no units)

Mean difference (95% CI)

Voxelwise Δ Ktrans (min−1)

Mean difference (95% CI)

Voxelwise Δ vp (no units)

Mean difference (95% CI)

Pre/2 weeks

Pre/6 months

Pre/2 weeks

Pre/6 months

Pre/2 weeks

Pre/6 months

1

0.11 (0.09,0.13)***

 

0.04 (0.03, 0.04)***

 

0.009 (0.005,0.14)***

 

2a

 

− 0.02 (− 0.04, 0.002)

 

− 0.06 (− 0.07,− 0.06)***

 

− 0.02 (− 0.02, − 0.01)***

3

0.004 (− 0.008, 0.16)

− 0.20 (− 0.22, − 0.18)***

0.04 (0.03,0.05)***

− 0.12 (− 0.13, − 0.10)***

0.02 (0.02, 0.03)***

− 0.03 (− 0.04,− 0.03)***

4

0.01 (0.008,0.02)***

− 0.02 (− 0.03,− 0.005)**

− 0.02 (− 0.02, − 0.01)***

− 0.08 (− 0.09,− 0.08)***

0.004 (0.003, 0.006)***

− 0.03 (− 0.04, − 0.03)***

5

− 0.07 (− 0.09, − 0.06)***

− 0.13 (− 0.16, − 0.11)***

− 0.001 (− 0.004, 0.003)

− 0.03 (− 0.03, − 0.02)***

− 0.007 (− 0.01, − 0.005)***

− 0.004 (− 0.007, 0.00)*

All

− 0.004 (− 0.01, 0.004)

− 0.09 (− 0.10, − 0.08)***

0.009 (0.005, 0.01)***

− 0.07 (− 0.074,− 0.067)***

0.008 (0.007, 0.01)***

− 0.02 (− 0.022, − 0.018)***

  1. Statistically significant values (p ≤ 0.05) are shown in bold
  2. P value calculated using repeated measures ANOVA or repeated measures mixed-effects model. Post hoc analysis of pairwise comparisons between different timepoints was performed using the Bonferroni method. ***≤ 0.001; **≤ 0.01; *≤ 0.05.
  3. aDifference between post-treatment timepoints shown as no pre-treatment imaging dataset.
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