Figure 3 | Scientific Reports

Figure 3

From: Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder

Figure 3

ROC analyses and scatter dots for multivariate predictive of full models of cognitive reserve (top, A, B) and cognitive impairment (down, C, D). ROC curves were generated by two binary regression logistic models using neurotrophic factors and alcohol-related variables as predictors following a backward stepwise entry method. (A) ROC curve for the full model 1 of cognitive reserve: “plasma concentrations of NT-3”, “age at onset of consumption” and “age at development of dependence”. (B) Scatter plot of the predictive probabilities for full model 1 of cognitive reserve (U = 18, p < 0.001). (C) ROC curve for the full model 2 of cognitive impairment: “plasma concentrations of BDNF”, “age at onset of consumption”, “length of AUD diagnosis”, “severity criteria”, and “duration of abstinence”. (D) Scatter plot of the predictive probabilities for the full model 2 of cognitive impairment (U = 69, p < 0.001). The lines of the scatterplots are means and standard deviations. CI cognitive impairment.

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