Figure 5

TLR2, TLR4, TLR7, and TLR9 receptors do not interfere in tumor regression in response to BCG treatment. C57BL/6 WT, TLR2^−/−, TLR4^−/−, TLR7^−/− and TLR9^−/− mice were submitted to the subcutaneous tumor model and BCG treatment. Tumor growth curves are shown for TLR2^−/− (A), TLR4^−/− (B), TLR7^−/− (C) and TLR9^−/− (D). The final volumes (day 22) are shown in Figure (E). Data represents mean and standard deviation from the results of at least two independent experiments. C57BL/6 WT data represents the summary of control animals from all in vivo experiments comparing WT and KO mice. *Statistically significant compared to the respective untreated control, ****P ≤ 0.0001. ^#Statistically significant compared to C57BL/6 WT mock not treated, ^#P ≤ 0.05, ^##P ≤ 0.01, ^####P ≤ 0.0001.