Figure 1
Brain regions showing significantly lower GMV in patients with late-life depression compared to healthy controls following whole-brain voxel-wise analysis. Three regions were identified: the left temporal, left parietal and right occipital regions. Areas associated with lower GMV in LLD are shown in yellow in (A) the left lateral view and (B) the bottom view. Boxplots of GMVs and SUVRs in each region are also presented: GMV in (C) the left temporal, (D) the left parietal, and (E) the right occipital regions; SUVR in (F) the left temporal region, (G) the left parietal region, and (H) the right occipital region. GMVs in these regions were significantly lower in LLD than in healthy controls (C–E), whereas SUVRs in these regions did not differ between groups (F–H). Y-axis represents mean voxel values in each cluster. HC healthy control, LLD late-life depression.
