Table 2 Significantly differentially-expressed metabolites between the MDD patients with full remission and the healthy controls.

From: Metabolomics-based discrimination of patients with remitted depression from healthy controls using 1H-NMR spectroscopy

Metabolite

Chemical shift (ppm)

VIP score

Fold change

p

Succinic acid

2.394–2.397 (s)

1.32

0.85

< 0.001

Proline

2.322–2.357 (m)

1.79

0.75

< 0.001

Acetic acid

1.907–1.914 (s)

1.37

0.83

< 0.001

Creatine

3.918–3.926 (s)

1.03

0.89

0.001

Glutamine

2.403–2.409 (m)

0.79

0.93

0.005

Glycine

3.548–3.565 (s)

0.63

0.94

0.020

Pyruvic acid

2.357–2.369 (s)

0.77

0.91

0.032

Histidine

7.760–7.783 (s)

1.39

1.06

0.039

  1. MDD major depressive disorder, VIP variable importance in the projection, s singlet, m multiplet.
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