Table 3 Functional pathway analysis of metabolites associated with MDD with full remission.

From: Metabolomics-based discrimination of patients with remitted depression from healthy controls using 1H-NMR spectroscopy

Pathway name

Match status

Metabolitesa

P

FDR

Impact

Alanine, aspartate and glutamate metabolism

3/24

Pyruvic acid, glutamine, succinic acid

< 0.001

0.002

0.207

Aminoacyl-tRNA biosynthesis

4/75

Histidine, glutamine, glycine, proline

< 0.001

0.002

0.000

Arginine and proline metabolism

4/77

Glutamine, proline, creatine, pyruvic acid

< 0.001

0.002

0.134

Nitrogen metabolism

3/39

Glutamine, histidine, glycine

< 0.001

0.004

0.000

Glycine, serine and threonine metabolism

3/48

Glycine, creatine, pyruvic acid

< 0.001

0.006

0.188

Taurine and hypotaurine metabolism

2/20

Pyruvic acid, acetic acid

0.002

0.020

0.022

Citrate cycle (TCA cycle)

2/20

Succinic acid, pyruvic acid

0.002

0.020

0.105

Glycolysis or Gluconeogenesis

2/31

Pyruvic acid, acetic acid

0.004

0.041

0.096

Pyruvate metabolism

2/32

Pyruvic acid, acetic acid

0.005

0.041

0.282

  1. MDD major depressive disorder, FDR false discovery rate, TCA tricarboxylic acid.
  2. aMetabolites for which p < 0.05 were selected.
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