Figure 1 | Scientific Reports

Figure 1

From: Patrolling human SLE haematopoietic progenitors demonstrate enhanced extramedullary colonisation; implications for peripheral tissue injury

Figure 1

Circulating and niche haematopoietic progenitors have different transcriptomic signatures, irrespective of disease status. (A) PCA analysis indicating the transcriptional clustering of human CD34+ progenitors from SLE PB (red squares, n = 6), SLE BM (orange squares, n = 10), Healthy BM (blue squares, n = 3) and Healthy PB (green squares, n = 7). (B) Heatmap representation of 12,659 DEG depicting clustering of BM- and PB-derived haematopoietic progenitors in Healthy and SLE individuals. (C) PCA analysis, heatmap and scatter plots indicating the transcriptional clustering of human CD34+ progenitors from Healthy PB versus BM and SLE PB versus BM. EdgeR analysis indicated 2149 DEG between BM and PB CD34+ progenitors, while in SLE samples, 7072 DE genes were detected between PB and BM (FDR < 0.05).

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