Figure 2

Different transcriptomic signatures in SLE PB and BM progenitors. (A) DEG between SLE BM-derived and PB-derived progenitors were used as an input on CLINVAR database, using as a reference cut-off the DEG found between healthy BM-derived and PB-derived progenitors. Graphical representation showing genes found to be either enriched in SLE (dark red) or Healthy (light green) progenitors, from genes reported in the CLINVAR database (p = 0.049). A heatmap of these DE genes indeed indicated higher expression levels in SLE PB-derived CD34⁺, in comparison to SLE BM-derived CD34⁺. (B) KEGG pie chart analysis of DEG between SLE-derived BM and PB CD34⁺ progenitors (red), and Healthy BM vs PB-derived (green). Pie chart connecting lines indicate kappa-score relations. Heatmaps indicating DEG that shown to be enriched in Healthy-derived PB (purple) when compared to Healthy-derived BM (light orange) progenitors, and SLE-derived PB (red) when compared to SLE-derived BM (black) progenitors. All analyses were performed with an FDR < 0.05 (Bonferroni and Heidelberg) correction.