Figure 4 | Scientific Reports

Figure 4

From: Patrolling human SLE haematopoietic progenitors demonstrate enhanced extramedullary colonisation; implications for peripheral tissue injury

Figure 4

Altered kinetics of SLE CD34+ progenitors in BM and spleen. (A) Schematic representation of the xenotransplantation procedure of human PB CD34+ in 2–3-month-old mice, N = 14. (B) Mice were sacrificed at designated time intervals and the BM-derived cells were subjected into immunostaining with antibodies against humanonly surface markers, in order to assess human cell presence. (C) Mice were sacrificed at designated time intervals and the spleen-derived cells were subjected into immunostaining with antibodies against human-only surface markers, in order to assess human cell presence. Lympho-gates (triangle), granulo-gates (square) and mono-gates (circle) represent different immune cell subpopulations and therefore examined separately. Box plots indicate the average percentages of total lymphocyte populations on all time-points. Paired Student’s T-test.

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