Table 4 Multivariate logistic regression analysis for the presence of subclinical atherosclerosis with serum Klotho and KL PBCs mRNA levels as independent variables.

From: Klotho as a biomarker of subclinical atherosclerosis in patients with moderate to severe chronic kidney disease

 

Unadjusted

Model 1

Model 2

Model 3

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

Serum Klotho (pg/mL)

0.993 (0.99–0.996)

 < 0.001

0.992 (0.988–0.996)

 < 0.001

0.992 (0.988–0.996)

 < 0.001

0.993 (0.988–0.998)

0.003

PBCs KL mRNA (a.u.)

0.291 (0.12–0.707)

0.006

0.24 (0.086–0.673)

0.007

0.218 (0.069–0.694)

0.01

0.260 (0.076–0.892)

0.032

  1. OR values are expressed per unit variation.
  2. Model 1 was adjusted by age, hypertension, current smokers, diabetes mellitus, hyperlipidemia.
  3. Model 2 was Model 1 adjusted by macroalbuminuria and eGFR.
  4. Model 3 was Model 2 adjusted by serum levels of IL6 and TNFα/IL10 and PBCs mRNA levels of IL6 and TNF/IL10.
  5. eGFR estimated glomerular filtrate rate, IL interleukin, TNFα tumor necrosis factor.
Back to article page