Table 2 Associations of a-FABP with central hemodynamic indices and key cardiac structural and functional parameters.

From: Association of free fatty acid binding protein with central aortic stiffness, myocardial dysfunction and preserved ejection fraction heart failure

(Per 10 ng/mL a-FABP increment)

Uni-variate model

Multi-variate model 1

Multi-variate model 2

Coef. (95% CI)

p value

Coef. (95% CI)

p value

Coef. (95% CI)

p value

Central and peripheral hemodynamic indices

CSP (mmHg)

3.05 (1.60, 4.51)

0.001

2.72 (1.23, 4.20)

< 0.001

2.00 (0.78, 3.21)

0.001

CDP (mmHg)

1.45 (0.68, 2.21)

0.01

1.08 (0.19, 1.97)

0.018

0.57 (− 0.13, 1.28)

0.11

CPP (mmHg)

2.35 (1.16, 3.54)

< 0.001

1.59 (0.73, 2.45)

< 0.001

1.42 (0.45, 2.39)

0.004

PPA (ratio)

0.001 (− 0.03, 0.03)

0.90

0.005 (− 0.03, 0.04)

0.77

0.002 (− 0.004, 0.01)

0.50

AIx (%)

0.85 (0.25, 1.45)

0.006

0.64 (0.05, 1.24)

0.035

0.37 (− 0.27, 1.01)

0.26

Cardiac structure and function

Left ventricular mass index (gm/m2*)

2.23 (− 0.54, 1.80)

0.001

2.07 (1.06, 3.09)

< 0.001

1.20 (0.14, 2.25)

0.026

TDI-e′ (average) (cm/s)

− 0.26 (− 0.37, − 0.15)

< 0.001

− 0.17 (− 0.27, − 0.07)

0.001

− 0.11 (− 0.22, − 0.01)

0.036

E/TDI-e′ (average)

0.69 (0.40, 0.97)

< 0.001

0.34 (0.15, 0.53)

< 0.001

0.20 (0.003, 0.40)

0.046

TDI-s′ (average) (cm/s)

− 0.12 (− 0.20, − 0.04)

0.005

− 0.07 (− 0.15, 0.01)

0.089

− 0.02 (− 0.11, 0.06)

0.59

GLS (%)

0.30 (0.17, 0.44)

< 0.001

0.27 (0.14, 0.41)

< 0.001

0.18 (0.04, 0.33)

0.013

  1. *In which model body mass index was not entered. Multi-variate Model 1: Adjusted for age, gender; Multi-variate Model 2: Model 1 plus body mass index (BMI), hypertension (yes/no), diabetes mellitus (yes/no), active smoking status (yes/no), coronary artery disease (yes/no), stroke (yes/no), renal function (eGFR).
  2. AIx, aortic augmentation index; CSP, central systolic pressure; CDP, central diastolic pressure; CPP, central pulse pressure; GLS, global LV longitudinal systolic myocardial strain; PPA, peripheral pulse pressure amplification; TDI-e′, peak myocardial diastolic relaxation velocity on tissue-based Doppler; E/TDI-e′, mitral inflow E wave divided by TDI-e′; TDI-s′, peak myocardial systolic relaxation velocity of tissue-based Doppler.
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