Figure 2
From: Microglial morphology in Alzheimer’s disease and after Aβ immunotherapy
Quantification and illustration of the microglial morphological features after a 3D-reconstruction. (A) cell body volume increased in AD (n = 10) compared to controls (n = 10), and (B) total process length increased in iAD (n = 15) compared to AD (n = 10). Illustration of microglial cells representative of the median cell body volume and total length for each group. Total n = 35 cases. Left column: maximum intensity projection of the confocal Z-stacks (green—microglial marker Iba1; red—cell nuclei identified with the fluorescent DNA stain DAPI). Right column: 3D-reconstructed models of selected microglia, showing AD with larger body volume than control, and iAD with more extended total process length than AD. Brain area: inferior parietal lobule. Scale bar = 10 μm.
