Table 1 Distribution of the proportion of each morphological category (%) in controls, AD and immunised AD groups.

From: Microglial morphology in Alzheimer’s disease and after Aβ immunotherapy

 

Control

AD

iAD

P value1

P value2

P value3

Total number of microglia

49 (26–88)

53 (17–100)

114 (49–190)

0.898

0.032

0.018

Ramified (%)

8.54 (1.94–26.48)

3.45 (0.00–7.06)

14.49 (9.09–25.81)

0.012

< 0.001

0.034

Reactive (%)

57.01 (42.86–67.15)

60 (49.53–66.40)

55.08 (31.88–65.45)

0.707

0.732

0.998

Amoeboid (%)

26.98 (19.36–37.86)

33.33 (25.07–47.78)

29.32 (18.42–38.89)

0.831

0.318

0.186

Reactive + amoeboid (%)

91.46 (73.52–98.06)

96.55 (92.94–100)

85.00 (74.19–90.91)

0.012

< 0.001

0.034

  1. Values are median with IQR.
  2. P value by Kruskal–Wallis test with Benjamini–Hochberg correction for multiple testing.
  3. P value1: control vs. AD; P value2: AD vs. iAD. P value3: Control vs. iAD.
  4. Significant P value in bold.
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