Table 2 3D morphological features of microglia in controls AD and immunised AD cases.
From: Microglial morphology in Alzheimer’s disease and after Aβ immunotherapy
Control | AD | iAD | P value1 | P value2 | P value3 | |
|---|---|---|---|---|---|---|
Cell body volume (μm3) | 256.50 (189.00–386.00) | 313.00 (219.50–432.00) | 274.00 (189.00–421.00) | 0.049 | 0.218 | 0.313 |
Cell body sphericity | 0.652 (0.585–0.705) | 0.643 (0.578–0.717) | 0.646 (0.583–0.704) | 0.985 | 1.000 | 1.000 |
Number of primary processes | 6 (4–8) | 6 (3–9) | 6 (4–9) | 0.923 | 1.000 | 0.834 |
Total primary process length (μm) | 124.99 (75.67–176.35) | 110.84 (60.53–152.45) | 128.54 (84.01–169.19) | 0.102 | 0.061 | 0.544 |
Average primary process length (μm) | 19.56 (13.20–27.14) | 17.84 (12.10–24.64) | 18.99 (15.12–26.49) | 0.114 | 0.177 | 0.973 |
Average primary process straightness | 0.757 (0.707–0.801) | 0.758 (0.703–0.812) | 0.763 (0.717–0.809) | 0.631 | 0.866 | 0.838 |
Total number of junctions | 21 (11–35) | 19 (9–33) | 22 (11–36) | 0.317 | 0.290 | 0.730 |
Number of junctions per primary process | 3.40 (2.00–5.83) | 3.00 (1.80–5.29) | 3.70 (2.00–5.66) | 0.255 | 0.342 | 0.887 |
Total secondary process length (μm) | 110.38 (52.66–208.16) | 99.34 (37.41–191.32) | 129.28 (57.67–217.05) | 0.195 | 0.067 | 0.483 |
Total process length (μm) | 216.85 (117.32–363.15) | 191.20 (83.15–311.22) | 238.99 (131.70–359.83) | 0.105 | 0.032 | 0.506 |
