Table 3 Correlation of microglial morphological features with pan-Aβ, Aβ42 and ptau.
From: Microglial morphology in Alzheimer’s disease and after Aβ immunotherapy
Pan-Aβ | Aβ42 | ptau | Pan-Aβ | Aβ42 | ptau | ||||
|---|---|---|---|---|---|---|---|---|---|
Cell body volume (μm3) | Ctrl | rs = − 0.333 P = 0.751 | rs = − 0.188 P = 0.938 | rs = − 0.433 P = 0.607 | Average primary process straightness | Ctrl | rs = 0.430 P = 0.607 | rs = 0.370 P = 0.676 | rs = − 0.061 P = 1.000 |
AD | rs = − 0.224 P = 0.761 | rs = − 0.167 P = 0.877 | rs = 0.018 P = 0.979 | AD | rs = 0.139 P = 0.892 | rs = − 0.283 P = 0.705 | rs = 0.152 P = 0.871 | ||
iAD | rs = 0.165 P = 0.919 | rs = − 0.021 P = 0.982 | rs = − 0.036 P = 1.000 | iAD | rs = − 0.165 P = 0.919 | rs = 0.146 P = 0.905 | rs = − 0.036 P = 1.000 | ||
Cell body sphericity | Ctrl | rs = 0.055 P = 0.984 | rs = 0.079 P = 0.973 | rs = 0.006 P = 0.987 | Number of primary processes | Ctrl | rs = − 0.055 P = 0.984 | rs = 0.115 P = 0.980 | rs = − 0.043 P = 0.987 |
AD | rs = 0.588 P = 0.263 | rs = 0.017 P = 0.980 | rs = 0.673 P = 0.139 | AD | rs = − 0.455 P = 0.427 | rs = − 0.283 P = 0.705 | rs = − 0.103 P = 0.917 | ||
iAD | rs = 0.257 P = 0.757 | rs = 0.161 P = 0.923 | rs = − 0.327 P = 0.728 | iAD | rs = − 0.829 P < 0.001 | rs = − 0.525 P = 0.264 | rs = − 0.100 P = 0.957 | ||
Total secondary process length (μm) | Ctrl | rs = − 0.018 P = 0.974 | rs = 0.176 P = 0.947 | rs = − 0.427 P = 0.613 | Total number of junctions | Ctrl | rs = − 0.115 P = 0.980 | rs = 0.115 P = 0.980 | rs = − 0.421 P = 0.624 |
AD | rs = − 0.709 P = 0.113 | rs = − 0.583 P = 0.310 | rs = − 0.539 P = 0.315 | AD | rs = − 0.745 P = 0.080 | rs = − 0.567 P = 0.322 | rs = − 0.588 P = 0.263 | ||
iAD | rs = − 0.411 P = 0.445 | rs = − 0.464 P = 0.321 | rs = − 0.182 P = 0.909 | iAD | rs = − 0.521 P = 0.280 | rs = − 0.468 P = 0.339 | rs = − 0.155 P = 0.922 | ||
Average primary process length (μm) | Ctrl | rs = 0.018 P = 0.974 | rs = − 0.055 P = 0.984 | rs = − 0.189 P = 0.942 | Number of junctions per primary process | Ctrl | rs = − 0.418 P = 0.617 | rs = 0.127 P = 0.971 | rs = − 0.439 P = 0.603 |
AD | rs = − 0.527 P = 0.328 | rs = − 0.317 P = 0.682 | rs = − 0.358 P = 0.587 | AD | rs = − 0.600 P = 0.251 | rs = − 0.317 P = 0.682 | rs = − 0.673 P = 0.139 | ||
iAD | rs = 0.121 P = 0.899 | rs = − 0.161 P = 0.923 | rs = − 0.091 P = 0.970 | iAD | rs = − 0.156 P = 0.904 | rs = − 0.293 P = 0.698 | rs = − 0.264 P = 0.798 | ||
Total primary process length (μm) | Ctrl | rs = 0.224 P = 0.917 | rs = 0.248 P = 0.934 | rs = 0.030 P = 1.000 | Total process length (μm) | Ctrl | rs = 0.030 P = 0.991 | rs = − 0.079 P = 0.973 | rs = − 0.128 P = 0.975 |
AD | rs = − 0.733 P = 0.093 | rs = − 0.067 P = 0.956 | rs = − 0.285 P = 0.681 | AD | rs = − 0.794 P = 0.043 | rs = − 0.400 P = 0.567 | rs = − 0.418 P = 0.486 | ||
iAD | rs = − 0.516 P = 0.059 | rs = − 0.461 P = 0.084 | rs = − 0.082 P = 0.968 | iAD | rs = − 0.503 P = 0.306 | rs = − 0.514 P = 0.276 | rs = − 0.100 P = 0.957 | ||
