Figure 5
From: NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice
NOTUM overexpression decreases adipocyte hypertrophy in iWAT, preserves BAT morphology, and increases mitochondrial DNA content in WATs. Tissue samples were from mice described in Fig. 1a–j. Average adipocyte size, (a) and total adipocyte number, (b) of iWAT were determined as described in the “Material and methods” section. n = 10 per group. (c) Representative H&E stained histological sections of iBAT are shown. (d) Mitochondrial DNA (mtDNA) contents of eWAT, iWAT, and iBAT are shown (n = 9–12). Symbols:*: p < 0.05, AAV-GFP versus AAV-Notum, as determined by Student’s t-test.
