Figure 7
From: NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice
NOTUM overexpression leads to substantial changes in global gene expression in iWAT of chow diet-fed mice. RNA-seq analysis were performed on iWAT samples collected from the same chow diet fed mice as described in Fig. 6. (a) Wnt target genes that were differentially expressed between the AAV-Notum and AAV-GFP groups were shown. (b) qPCR data of the same Wnt target genes described in (a) are shown. (c) Repressed functional clusters in the iWAT of AAV-Notum treated mice compared to the AAV-GFP treated mice are shown. (d) Heat map of log2 fold changes of ECM cluster transcripts in the iWAT of AAV-Notum treated mice compared to those of the AAV-GFP treated mice are shown. Symbols: *: p < 0.05, **: p < 0.01, ****: p < 0.0001, AAV-GFP versus AAV-Notum, as determined by Student’s t-test. ECM Extracellular matrix, EGF Epidermal growth factor, FC Fold change, ND Not detectable.
