Table 5 Test characteristics of probable UIP pattern on CT alone and together with clinical features for IPF diagnosis in patients with CT pattern of non-definite UIP.
Development cohort (n = 142) | Validation cohort (n = 94) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Model criteria | Sens | Spec | PPV | NPV | Accuarcy | Sens | Spec | PPV | NPV | Accuarcy | |
Probable UIP | 72.1 (59.2–82.9) | 63.0 (51.5–73.4) | 59.5 (51.5–67.0) | 75.0 (66.0–82.3) | 66.9 (58.5–74.6) | 68.3 (51.9–81.9) | 67.9 (53.7–80.1) | 62.2 (51.4–72.0) | 73.5 (63.0–81.8) | 68.1 (57.7–77.3) | |
Probable UIP and male with age ≥ 60 years | 41.0 (28.6–54.3) | 92.6 (84.6–97.2) | 80.6 (64.6–90.5) | 67.6 (62.6–72.2) | 70.4 (62.2–77.8) | 24.4 (12.4–40.3) | 88.7 (77.0–95.7) | 62.5 (39.8–80.8) | 60.3 (55.4–64.9) | 60.6 (50.0–70.6) | |
Probable UIP and low lymphocyte count (≤ 15%) in BAL fluid | 54.1 (40.9–66.9) | 88.9 (80.0–94.8) | 78.6 (65.5–87.6) | 72.0 (66.0–77.3) | 73.9 (65.9–80.9) | 55.7 (37.4–69.3) | 86.8 (74.7–94.5) | 75.9 (59.8–86.9) | 70.8 (63.1–77.4) | 72.3 (62.2–81.1) | |
Probable UIP, male with age ≥ 60 years and low lymphocyte count (≤ 15%) in BAL fluid | 34.4 (22.7–47.7) | 97.5 (91.4–99.7) | 91.3 (71.9–97.7) | 66.4 (62.1–70.4) | 70.4 (62.2–77.8) | 17.1 (7.2–32.1) | 92.5 (81.8–97.9) | 63.6 (35.5–84.8) | 59.0 (55.1–62.8) | 59.6 (49.0–62.8) | |
Probable UIP and either low lymphocyte count (≤ 15%) in BAL fluid or male with age ≥ 60 years | 60.7 (47.3–72.9) | 84.0 (74.1–91.2) | 74.0 (62.4–83.0) | 73.9 (67.2–79.7) | 73.9 (65.9–80.9) | 73.3 (60.3–83.9) | 73.5 (55.6–87.1) | 83.0 (73.2–89.7) | 61.0 (49.5–71.3) | 73.4 (63.3–82.0) | |
Probable UIP, low lymphocyte count (≤ 15%) in BAL fluid and either male or age ≥ 60 years | 52.5 (39.3–65.4) | 90.1 (81.5–95.6) | 80.0 (66.5–89.0) | 71.6 (65.7–76.8) | 73.9 (65.9–80.9) | 51.2 (35.1–67.1) | 90.6 (79.3–96.9) | 80.8 (63.4–91.1) | 70.6 (63.4–76.9) | 73.4 (63.3–82.0) | |
