Table 2 Hub genes involved in SARS-CoV-2 infection of normal human bronchial epithelial cells.

From: Comparative transcriptome analyses reveal genes associated with SARS-CoV-2 infection of human lung epithelial cells

Hub nodes

Degree

Closeness

Betweenness

GSE147507

GSE153970

Absolute FC

P-value

Absolute FC

P-value

IL6

39

52.66

1061.909

7.59

6.59E−20

5.87

4.78E−14

IL1B

35

50.16

715.3514

2.11

9.62E−25

1.67

5.66E−11

CXCL8

34

49.66

382.1511

5.28

2.6E−112

2.38

5.98E−24

MMP9

30

47.91

832.9246

5.50

4.86E−23

2.41

1.51E−14

CXCL1

26

43.95

143.7859

2.64

2.27E−38

2.63

3.04E−19

CSF2

23

43.83

194.193

7.63

8.01E−09

3.97

6.06E−05

CCL20

22

43.16

99.528

9.31

1.37E−71

3.44

1.25E−51

ICAM1

21

42.83

130.012

3.66

1.24E−38

1.53

6.44E−05

IL1A

19

40.28

23.204

2.14

8.95E−16

1.71

5.09E−10

CXCL2

19

40.45

39.909

2.65

9.33E−15

2.15

1.75E−09

CSF3

18

39.61

18.700

32.18

7.74E−18

9.36

1.77E−61

SAA1

17

38.95

142.325

5.04

8.62E−48

1.56

1.53E−06

NFKB2

17

39.61

122.589

2.01

1.82E−15

1.78

3.29E−08

PI3

17

40.75

1217.573

3.72

4.64E−07

1.93

2.59E−07

TNFAIP3

17

38.56

46.582

3.11

3.38E−47

1.73

1.11E−08

CXCL3

17

39.28

22.292

4.67

2.38E−14

3.67

9.64E−15

CXCL5

15

38.11

8.458

11.70

6.87E−27

4.18

4.61E−35

CXCL6

14

37.61

7.723

3.26

0.016423

2.74

5.63E−13

EDN1

13

39

122.702

2.13

1.19E−08

1.88

1.94E−10

HBEGF

11

35.95

144.650

2.52

8.02E−27

2.75

2.78E−15

BCL2A1

11

36.11

139.405

4.97

6.48E−10

3.30

4.38E−20

NFKBIZ

11

35.4

139.988

1.82

5.76E−12

2.28

7.37E−29

S100A12

11

37.5

25.471

2.21

0.0438

5.28

2.45E−14

PLAUR

9

35.2

74.008

1.65

2.5E−06

2.25

2.30E−16

BIRC3

9

34.53

8.979

3.36

5.7E−21

1.60

2.55E−05

IL36G

9

34.95

0.821

6.79

9.54E−49

14.64

1.43E−88

LIF

9

34.56

3.828

2.52

1.05E−26

2.60

8.75E−10

SERPINB2

8

34.45

0.689

1.68

4.64E−07

4.55

2.23E−33

SPRR1A

8

29.28

86.666

1.67

0.00927

5.88

1.43E−14

SPRR1B

8

29.28

86.666

1.53

0.001373

3.48

1.15E−38

IVL

8

29.11

136

2.02

2.08E−11

2.97

3.49E−20

DDX58

8

33.9

109

1.50

0.0088

1.55

2.54E−05

SPRR2A

8

29.28

86.666

3.57

4.3E−20

18.08

1.04E−152

ZC3H12A

7

33.56

4.0976

3.24

5.01E−30

1.92

3.20E−12

S100A9

7

33.78

0.333

2.21

7.38E−35

2.97

6.39E−27

PDGFB

7

33.78

138.966

2.06

6.93E−07

1.95

3.74E−08

IL7R

7

33.4

4.91

1.83

0.013

2.48

0.0414

MAP3K8

6

32.73

0.44

2.22

0.005

2.25

1.96E−11

IKBKE

6

31.98

3.31

1.71

0.00017

1.68

9.13E−07

MAF

3

30.48

136

− 1.73

3.26E−06

− 1.81

0.00755

ADAM8

3

29.11

268

2.18

3.26E−06

2.33

3.83E−15

GBP5

3

29.73

31.94

3.84

0.02372

4.26

4.21E−10

Back to article page