Figure 6

Calgranulin A (Cal-A) distribution in concentric COM. (a) Scanning electron microscope (SEM) image of a thin section. (b) Merged images of multi-IF staining and SEM of the thin section. The positions of the concentrically aligned gap spaces shown in the SEM image are overlapped with the positions of Cal-A lamination. (c) SEM image of a crashed concentric COM. (d) Enlarged image of the white box area in (c). The directions from the center to the outside of concentric COM stones are shown with dashed white arrows. The gap space between the COM crystals is shown with solid white arrows.