Table 1 Baseline characteristics.
Variables | Very low-dose | Standard dose | p value |
|---|---|---|---|
(N = 106) | (N = 100) | ||
Male, n (%) | 73 (68.9%) | 72 (72.0%) | 0.623 |
Age (years) | 61.7 ± 15.2 | 63.5 ± 13.4 | 0.363 |
Body mass index (kg/m2) | 23.5 ± 3.5 | 25.6 ± 4.1 | < 0.001 |
Etiology | 0.843 | ||
Ischemic cardiomyopathy, n (%) | 31 (29.2%) | 28 (28.0%) | |
Non-ischemic cardiomyopathy, n (%) | 75 (70.8%) | 72 (72.0%) | |
SBP (mm Hg) | 102.8 ± 12.0 | 118.7 ± 13.8 | < 0.001 |
SBP < 100 mmHg, n (%) | 40 (37.7%) | 6 (6.0%) | < 0.001 |
Heart rate (/min) | 73.0 ± 14.6 | 71.6 ± 12.7 | 0.451 |
NYHA classification, n (%) | 0.930 | ||
II | 95 (89.6%) | 90 (90.0%) | |
III | 11 (10.4%) | 10 (10.0%) | |
Medical history, n (%) | |||
Hypertension | 55 (51.9%) | 74 (74%) | 0.001 |
Diabetes | 23 (21.7%) | 36 (36%) | 0.022 |
Dyslipidemia | 13 (12.3%) | 19 (19.0%) | 0.172 |
Myocardial infarction | 20 (18.9%) | 23 (23.0%) | 0.443 |
Stroke | 11 (10.4%) | 9 (9.0%) | 0.756 |
Atrial fibrillation | 35 (33.0%) | 32 (32.0%) | 0.915 |
Chronic kidney disease | 41 (38.7%) | 37 (37.0%) | 0.847 |
Laboratory parameter | |||
Blood urea nitrogen (mg/dL) | 21.8 ± 10.6 | 22 ± 9.8 | 0.910 |
Creatinine (mg/dL) | 1.1 ± 0.4 | 1.1 ± 0.4 | 0.854 |
eGFR (mL/min/1.73m2) | 67.2 ± 19.9 | 66.2 ± 19.2 | 0.716 |
Sodium (mmol/L) | 140.2 ± 2.6 | 140.9 ± 2.7 | 0.101 |
Potassium (mmol/L) | 4.6 ± 0.5 | 4.6 ± 0.5 | 0.847 |
Hemoglobin (g/dL) | 13.4 ± 1.8 | 13.8 ± 2.1 | 0.171 |
NT-proBNP (pg/mL) | 2750.9 ± 4453.6 | 2311.1 ± 3662.1 | 0.475 |
Echocardiograhic parameter | |||
LVEF (%) | 25.4 ± 6.1 | 27.3 ± 5.9 | 0.026 |
LVEDD (mm) | 65.5 ± 9.4 | 64.7 ± 7.0 | 0.447 |
Pre-SV treatment therapy | |||
Angiotensin-converting enzyme inhibitor, n (%) | 11 (10.4%) | 13 (13.0%) | 0.558 |
Angiotensin II receptor blocker, n (%) | 95 (89.6%) | 87 (87.0%) | 0.558 |
Beta-blocker, n (%) | 96 (90.6%) | 93 (93.0%) | 0.526 |
Mineralocorticoid receptor antagonist, n (%) | 85 (80.2%) | 75 (75.0%) | 0.371 |
Loop diuretics, n (%) | 89 (84%) | 83 (83.0%) | 0.852 |
Ivabradine, n (%) | 21 (19.8%) | 12 (12.0%) | 0.127 |
Implantable cardioverter defibrillator, n (%) | 40 (37.7%) | 35 (35.0%) | 0.723 |
Cardiac resynchronization therapy, n (%) | 11 (10.4%) | 15 (15.0%) | 0.305 |