Figure 3

The vascular endothelial growth factor (VEGF) network in kidney grafts from rats receiving vehicle or Rapa. Quantitative real-time PCR on days 1–7 (a) and immunohistochemistry on day 7 (b) for VEGF-A. Representative photomicrographs are shown. mRNA expression of the VEGF receptors 1 (VEGF-R1; c) and 2 (VEGF-R2; d) and the VEGF co-receptor neuropilin-1 (e) as assessed with quantitative real-time PCR. n = 4–6. *P < 0.05, **P < 0.01, ***P < 0.001.