Table 1 Fold difference in microRNA expression CSII compared to MDI therapy at study end-point.

microRNA	Cycle threshold (CT) (mean)			Fold difference expression^¶	P-value
microRNA	CSII (end point—baseline)	MDI (end point—baseline)	CSII-MDI	Fold difference expression^¶	P-value
Increased expression (both arms) compared to baseline
miR-106a	− 3.58	− 9.99	6.41^§	85	0.026
miR-483-5p	− 6.92	− 10.93	4.01^§	16	0.048
Reduced expression (both arms) compared to baseline
miR-24	6.08	0.39	5.79^‡	55	0.0089
miR-21	10.45	4.30	6.15^‡	71	0.036
miR-328	9.75	2.53	7.22^‡	149	0.042
Differing expression (increased in one; reduced in other arm) compared to baseline
miR-99b	1.42	− 12.44	13.86^†	14,885	0.0048
miR-320	0.75	− 11.67	12.42^†	5474	0.011
miR-375	1.47	− 5.88	7.35^†	163	0.019
miR-28	2.96	− 5.64	8.59^†	386	0.026
miR-17	3.48	− 4.17	7.65^†	201	0.031
miR-92a	2.20	− 9.67	11.87^†	3746	0.042

Positive endpoint—baseline value indicates higher CT level (lower expression) at the end of follow-up. Negative value indicates lower CT level (higher expression) at the end of follow-up relative to baseline.
^†Expression at endpoint relative to baseline reduced in CSII, and increased in MDI.
^‡Expression at endpoint relative to baseline reduced in CSII, smaller reduction in MDI.
^§Expression at endpoint relative to baseline increased in CSII, greater increase in MDI.
^¶Calculated as 2^(CSII-MDI).
Significant P-values are highlighted in bold.

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