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Figure 1

From: Metformin attenuates renal tubulointerstitial fibrosis via upgrading autophagy in the early stage of diabetic nephropathy

Figure 1

Effects of metformin on renal histology and extracellular matrix expansion. (a) Renal histology based on H&E staining. Scale bar represents 50 μm. (b) Extracellular matrix expansion based on Masson staining. Scale bar represents 50 μm. (c) Statistical analysis of renal fibrotic areas in each group. *P < 0.01 vs. Sham group by ANOVA, #P < 0.01 vs. Sham and 4-week DN group by ANOVA, $P < 0.05 vs. 4-week DN/DN + Met group by ANOVA. 4W: 4-week; 12W: 12-week; Met: metformin.

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