Table 1 Blood glucose and renal function of rats in each group (n = 6).

From: Metformin attenuates renal tubulointerstitial fibrosis via upgrading autophagy in the early stage of diabetic nephropathy

Group

Time (w)

Number

Blood glucose (mol/L)

BUN (mmol/L)

SCr (μmol/L)

Sham

4

6

6.05 ± 0.82

9.06 ± 1.25

38.31 ± 3.02

12

6

5.95 ± 0.85

9.39 ± 1.08

40.61 ± 4.13

DN

4

6

25.00 ± 1.92*

9.97 ± 1.43

44.95 ± 6.17

12

6

30.80 ± 2.01*$

14.61 ± 1.62*$

56.71 ± 6.45*$

DN + Met

4

6

16.48 ± 1.13*#

9.38 ± 1.80

39.53 ± 4.72

12

6

19.12 ± 1.13*#

12.44 ± 1.73*△

47.08 ± 5.43*#

  1. All data were shown as mean ± SD (n = 3).
  2. BUN: blood urea nitrogen; SCr: serum creatinine; Sham: control group; DN: diabetic nephropathy group; Met: metformin.
  3. *P < 0.01 vs. Sham group by ANOVA, #,△P < 0.01 vs. DN group by ANOVA, $P < 0.05 vs. 4-week DN and DN + Met group by ANOVA.
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