Table 2 Comparison between BWT, KW/BWT, and 24-h urine protein in each group (n = 6).

From: Metformin attenuates renal tubulointerstitial fibrosis via upgrading autophagy in the early stage of diabetic nephropathy

Group

Time (w)

Number

BWT (g)

KW/BWT (%)

24-h urine protein (mg)

Sham

4

6

496.67 ± 19.67

0.59 ± 0.07

11.37 ± 1.57

12

6

532.68 ± 28.68

0.57 ± 0.03

8.59 ± 2.00

DN

4

6

365.33 ± 19.00*

1.16 ± 0.14*

66.37 ± 6.86*

12

6

332.17 ± 27.81*

1.81 ± 0.13*$

97.66 ± 9.76*$

DN + Met

4

6

429.83 ± 23.84*#

0.88 ± 0.06*#

51.99 ± 2.54*△

12

6

396.33 ± 31.02*#

1.48 ± 0.24*#

82.73 ± 9.28*#

  1. All data were shown as mean ± SD (n = 3).
  2. BWT: body weight; KW: kidney weight; Sham: control group; DN: diabetic nephropathy group; Met: metformin.
  3. *P < 0.01 vs. Sham group by ANOVA, #,△P < 0.01 vs. DN group by ANOVA, $P < 0.05 vs. 4-week DN/DN + Met group by ANOVA.
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