Table 2 Top 20 SNPs of GWAS results in all subjects for emphysema.

From: A genome-wide association study of quantitative computed tomographic emphysema in Korean populations

SNP

Nearest gene

Genetic locus

Chr

Position (bp)

Ref/Alt

ALL main model

MAF

P value

β

SE

N

rs117084279

PIBF1

13q22

13

73,444,485

T/C

0.021

8.85E−09

− 1.37

0.235

548

rs7339277

KLF12

13q22

13

74,350,128

A/G

0.056

1.40E−07

− 0.76

0.143

545

rs142659816

20q13

20

48,635,162

G/A

0.037

3.11E−07

− 0.91

0.175

548

rs56784511

KCNJ3

2q24

2

155,641,769

A/G

0.067

3.29E−07

− 0.71

0.137

548

rs66771402

7p14

7

42,567,077

C/T

0.304

5.06E−07

0.36

0.071

548

rs67354756

KCNJ3

2q24

2

155,640,196

C/G

0.069

6.35E−07

− 0.68

0.135

548

rs1917213

7p14

7

42,577,872

A/T

0.310

6.36E−07

0.36

0.071

548

rs76470312

8p21

8

23,887,223

A/G

0.019

9.45E−07

− 1.20

0.241

548

rs143675498

CDH18

5p14

5

19,850,049

A/G

0.013

1.33E−06

− 1.42

0.291

547

rs6719455

KCNJ3

2q24

2

155,640,626

C/A

0.104

1.62E−06

− 0.55

0.113

547

rs6897483

5p13

5

29,735,073

A/T

0.192

1.67E−06

0.40

0.082

548

rs6897957

5p13

5

29,735,311

A/T

0.192

1.67E−06

0.40

0.082

548

rs10041866

5p13

5

29,738,133

C/A

0.193

2.06E−06

0.39

0.081

548

rs6880736

5p13

5

29,739,430

C/A

0.193

2.06E−06

0.39

0.081

548

rs7704866

5p13

5

29,736,738

A/G

0.193

2.06E−06

0.39

0.081

548

rs79879780

AL354720.1

13q22

13

73,699,403

C/T

0.026

2.10E−06

− 1.00

0.209

548

rs16950278

LOC101927284

13q32

13

95,533,306

A/G

0.015

2.18E−06

− 1.34

0.279

548

rs73547640

LOC101927284

13q32

13

95,531,311

T/C

0.015

2.18E−06

− 1.34

0.279

548

rs2168555

5p13

5

29,732,700

T/C

0.192

2.24E−06

0.39

0.082

548

rs149086677

FBLN2

3p25

3

13,629,075

G/A

0.028

2.30E−06

− 0.90

0.188

548

  1. Model 1 was adjusted for Center, Age, Sex, Smoking event and Pack-years.
  2. ALL All patients, LNEI natural logarithm of emphysema index.
  3. *P value were less than 5.00E−06.