Table 2 Demographic and clinical data of JIA patient development and evaluation groups.

From: A peptide-based anti-Adalimumab antibody assay to monitor immune response to biologics treatment in juvenile idiopathic arthritis and childhood chronic non-infectious uveitis

 

Development group

Evaluation group

Number of patients (M/F)

18 (4/14)

29 (8/21)

Age (years) at inclusions (± SD)

10.9 (± 4.3)

10.1 (± 3.24)

Disease duration at study entry (years, ± SD)

4.6 (± 4.1)

4.7 (± 3.25)

Number of JIA patients (M/F)

16 (3/13)

25 (7/18)

JIA category

Oligoarthritis

7

13

Polyarthritis

6

8

Psoriasis

1

2

Enthesitis-related arthritis

2

2

Patients with uveitis: n (M/F)

9 (1/8)

16 (3/13)

JIA associated Uveitis (M/F)

7 (0/7)

12 (2/10)

Chronic non-infectious uveitis (M/F)

2 (1/1)

4 (1/3)

ANA positivity (%)

11 (61%)

21 (72%)

Concomitant treatment with MTX (number)

86% (13)

58% (17)

Duration (months) of concomitant MTX (± SD)

32.2 (± 29.4)

40.6 (± 32.4)

Duration (months) of Adalimumab (± SD)

29.3 (± 32.7)

26.7 (± 28.2)

JIA inactive disease during drug administration (number/JIA patients)

69% (11/16)

64% (16/25)

Uveitis inactive disease during drug administration (number/uveitis patients)

78% (7/9)

87.5% (14/16a)

For JIA patients

JADAS-10 (± SD) at Adalimumab introduction

13.7 (± 5.03)

14.8 (± 9.45)

JADAS-10 at ADAbs testing

2.7 (± 3.78)

2.8 (± 3.24)

  1. aOne patient with JIA was diagnosed with JIA-associated uveitis during treatment.