Table 3 Logistic regression analyses of DESH and Evans index for cognitive impairment in the participants who underwent MRI (n = 1384).

MRI imaging findings			Univariate			Multivariate (model 1)			Multivariate (model 2)
MRI imaging findings			OR	95% CI	p value	OR	95% CI	p value	OR	95% CI	p value
MMSE		N
< = 25/ > 25		373/1011
EI models
EI	= < 0.3	343/949	ref			ref			ref
EI	> 0.3	30/62	1.33	0.85–2.10	0.207	0.95	0.58–1.55	0.851	0.98	0.59–1.59	0.926
EI	= < 0.28	366/1009	ref			ref			ref
EI	> 0.28	7/2	1.62	1.24–2.12	< 0.001	1.19	0.89–1.60	0.231	1.21	0.90–1.63	0.191
DESH models
DESH DESH	Absence	366/1009	ref			ref			ref
DESH DESH	Presence	7/2	9.64	1.99–46.65	0.005	7.83	1.50–40.82	0.015	8.50	1.61–44.88	0.012
DESH-expanded	Absence	361/1000	ref			ref			ref
DESH-expanded	Presence	12/11	3.02	1.32–6.90	0.009	2.39	1.01–5.68	0.048	2.60	1.08–6.25	0.032
< = 26/ > 26		497/887
EI model
EI	= < 0.3	456/836	ref			ref			ref
EI	> 0.3	41/51	1.47	0.96–2.25	0.075	1.05	0.66–1.66	0.833	1.08	0.68–1.71	0.742
DESH model
DESH	Absence	490/885	ref			ref			ref
DESH	Presence	7/2	6.32	1.30–30.54	0.022	4.90	0.95–25.25	0.057	5.41	1.04–28.01	0.044
< = 24/ > 24		274/1110
EI model
EI	= < 0.3	251/1041	ref			ref			ref
EI	> 0.3	23/69	1.38	0.84–2.26	0.197	0.98	0.58–1.65	0.942	1.00	0.59–1.71	0.975
DESH model
DESH	Absence	269/1106	ref			ref			ref
DESH	Presence	5/4	5.13	1.37–19.26	0.015	4.07	0.99–16.64	0.051	4.41	1.04–18.60	0.043

Multivariate analyses were performed by adjusting for age, sex, BMI and duration of education (< 10 years) in model 1, and adjusting for history of cerebrovascular diseases, history of hypertension, history of diabetes mellitus, history of hyperlipidemia, smoking history and drinking history in addition to model 1 in model 2.
95% CI 95% confidence interval, EI Evans index, BMI body mass index.

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