Table 3 Univariate and multivariate cox proportional hazards analysis of clinicopathological variables and hypoxia signature based on OS in the CGGA GBM validation cohort.

From: Proteomics-based prognostic signature and nomogram construction of hypoxia microenvironment on deteriorating glioblastoma (GBM) pathogenesis

Characteristic

CGGA

p

HR

95%CI

p

HR

95%CI

Univariate

Multivariate

Riskscore

0.01

1.96

1.16–3.32

0.075

1.69

0.95–3.02

Age(≥ 65)

0.92

1.06

0.39–2.90

   

Gender (Male)

0.10

1.51

0.92–2.48

0.14

1.46

0.89–2.4

Subtype (Mesenchymal)

0.04

1.74

1.02–2.99

   

Subtype (Neural)

0.29

0.59

0.22–1.57

   

Subtype (ProneuRal)

0.93

1.03

0.54–1.95

   

IDH (WT)

0.24

1.37

0.81–2.34

   

Chemotherapy (YES)

 < 0.001

0.32

0.21–0.51

 < 0.001

0.40

0.25–0.64

Radiotherapy (YES)

 < 0.001

0.40

0.25–0.64

0.002

0.48

0.30–0.77

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