Figure 1
From: Metabolic rewiring is associated with HPV-specific profiles in cervical cancer cell lines
Metabolomic analysis of the altered carbohydrate metabolism of the four cervical cell lines. Selected biochemicals exhibiting salient changes among the four cell types are displayed as box plots. The relevant pathway map and a representative heat map is shown, including the major biochemical changes. Pathway schematics for Figs. 1, 2, 3, 4, 5 and 7, were prepared by GAM at Metabolon, Inc., utilizing established sources, including KEGG (https://www.genome.jp/kegg/) and published literature to confirm each biochemical step of the pathway. Green color indicates significant difference (P ≤ 0.05) between the groups shown, metabolite ratio of < 1.00; light green indicates narrowly missed statistical cut-off for significance 0.05 < P < 0.10, metabolite ratio of < 1.00; red indicates significant difference (P ≤ 0.05) between the groups shown, metabolite ratio of ≥ 1.00; light red indicates narrowly missed statistical cut-off for significance 0.05 < P < 0.10, metabolite ratio of ≥ 1.00, and non-coloured cells, indicates that mean values are not significantly different for that comparison. Each box plot provides a measure of scaled intensity, normalised by protein content. For further details see Extended Data Table 2.
