Figure 3 | Scientific Reports

Figure 3

From: Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria

Figure 3

Syndecan-1 is cleaved by matrix metalloproteinases in placental cells. Broad spectrum MMP inhibitor batimastat induced a dose-dependent reduction in syndecan-1 secretion relative to vehicle control (A) and caused a significant increase in cellular syndecan-1 (B), but no change in syndecan-1 mRNA expression (C). Like batimastat, ilomastat significantly reduced syndecan-1 secretion (D). The same effects of batimastat were observed in syncytialised first trimester cytotrophoblast stem cells, with significantly reduced syndecan-1 secretion (E), significantly increased cellular protein (F) and mRNA expression (G). Cellular studies were repeated n = 5 times. Data is expressed as mean ± SEM. *p < 0.05, **p < 0.01, ****p < 0.0001.

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