Table 1 Factors and limits in the experimental design.

From: Using a material database and data fusion method to accelerate the process model development of high shear wet granulation

Operation boundary

Formulation variable

Manipulated process variable

Mass fraction of cellulose material (%)

Liquid to solid ratio (g/g)

Impeller speed (s−1)

Granulator scale (L)

Upper limit

100

1.8

1200

2

Lower limit

0

0.025

350

1

Type

Continuous

Continuous

Continuous

Discrete