Table 2 The results of laboratory granulation experiments for model improvement.

From: Using a material database and data fusion method to accelerate the process model development of high shear wet granulation

No.

Scale (L)

Component 1

Mass fraction (%)

Component 2

Mass fraction (%)

Liquid to solid ratio (L/S)

Froude number

Impeller speed (rpm)

Smax

G50 (μm)

1

1

MCC PH101

64

Lactose 110M

36

0.858

4.212

1030

75.5

1400

2

1

MCC PH101

81

Lactose 200M

19

0.999

5.239

1149

82.7

1394

3

1

MCC PH101

95

Lactose 110M

5

1.333

3.178

895

92.2

2017

4

1

MCC PH101

38

Lactose 200M

62

0.315

0.975

496

41.3

205

5

1

HPMC E15LV

62

Anhydrous lactose

38

0.158

2.352

770

19.1

142

6

2

MCC PH101

81

Granulac 200

19

0.999

3.239

810

82.4

1054

7

1

MCC PH101

13

Lactose 110M

87

1.209

1.557

626

154.2