Table 3 The results of external validation experiments.

From: Using a material database and data fusion method to accelerate the process model development of high shear wet granulation

No.

Scale (L)

Component 1

Mass fraction (%)

Component 2

Mass fraction (%)

Liquid to solid ratio (L/S)

Froude number

Impeller speed (rpm)

Smax

Yobs G50 (μm)

Ypre (μm)

8

2

MCC PH101

64

Granulac 200

36

0.396

1.7

587

39.3

424

458

9

1

MCC PH101

81

Lactose 200M

19

0.862

2.878

852

71.4

1088

774

10

1

MCC PH101

95

Lactose 110M

5

0.882

2.619

812

61.0

978

798

11

1

HPMC E15LV

62

Anhydrous lactose

38

0.296

1.7

655

35.8

207

198

12

1

MCC PH101 (74.3%), HPMC E15LV(25.7%)

70

Anhydrous lactose

30

0.299

5.239

1149

30.6

194

158

13

2

MCC PH101

64

Granulac 200

36

0.658

2.212

670

65.2

641

632

14

1

MCC PH101

38

Lactose 200M

62

0.816

7.001

1200

107.1