Table 2 The clinical outcomes and complications in the patients who underwent frozen autograft reconstruction on the appendicular skeleton in the three age groups.
Generation | Children (≤ 14 years old) | AYAs (15 to 39 years old) | Older adults (≥ 40 years old) | P-value |
|---|---|---|---|---|
Case (n) | 27 | 37 | 16 | – |
Chemotherapy (n) | 27 | 35 | 8 | < 0.01 |
Oncological outcome (n) (%) | CDF 16 (59%) | CDF 16 (43%) | CDF 10 (63%) | 0.58 |
NED 5 (19%) | NED 6 (16%) | NED 1 (6%) | ||
AWD 2 (7%) | AWD 5 (14%) | AWD 3 (19%) | ||
DOD 4 (15%) | DOD 10 (27%) | DOD 1 (6%) DOOD 1 (6%) | ||
Median period of bone union (mos.) (range) | 6 (3–15) | 8 (3–21) | 10 (4–24) | 0.14 |
Bone union rate within 1 year | 94% | 94% | 63% | 0.06 |
Functional score (MSTS score) (n) (%) | Excellent 18 (86%) Good 2 (10%) Fair 1 (5%) Poor 0 (0%) | Excellent 23 (79%) Good 4 (14%) Fair 2 (7%) Poor 0 (0%) | Excellent 13 (87%) Good 1 (7%) Fair 1 (7%) Poor 0 (0%) | 0.98 |
5-year graft survival (%) | 80% | 86% | 79% | 0.79 |
Reasons for graft removal | ||||
Infection (n) (%) | 1 (4%) | 5 (14%) | 3 (19%) | 0.28 |
Fracture (n) (%) | 1 (4%) | 0 (0%) | 0 (0%) | 0.54 |
Non-union (n) (%) | 0 (%) | 0 (0%) | 0 (0%) | 1 |
Osteoarthritic change (n) (%) | 2 (7%) | 0 (0%) | 0 (0%) | 0.15 |
Recurrence (n) (%) | 3 (11%) | 2 (5%) | 1 (6%) | 0.86 |
Complications | ||||
Infection (n) (%) | 1 (4%) | 7 (19%) | 3 (19%) | 0.17 |
Fracture (n) (%) | 8 (30%) | 2 (5%) | 1 (6%) | 0.03 |
Non-union (n) (%) | 3 (11%) | 1 (3%) | 1 (6%) | 0.35 |
Limb deformity (n) (%) | 5 (19%) | 1 (3%) | 0 (0%) | 0.05 |
Osteoarthritic change (n) (%) | 4 (15%) | 5 (14%) | 0 (0%) | 0.37 |
Bone absorption (n) (%) | 1 (4%) | 3 (8%) | 2 (13%) | 0.56 |
Salvage amputation | ||||
Recurrence (n) (%) Infection (n) (%) | 2 (7%) 1 (4%) | 2 (5%) 3 (8%) | 1 (6%) 0 (0%) | 1 0.67 |
