Table 3 The clinical outcomes and complications in the patients who underwent free freezing procedure on the appendicular skeleton in the three age groups.
Generation | Children (≤ 14 years old) | AYAs (15 to 39 years old) | Older adults (≥ 40 years old) | P-value |
|---|---|---|---|---|
Case (n) | 11 | 21 | 5 | – |
Chemotherapy (n) (%) | 11 | 19 | 4 | 0.14 |
Oncological outcome (n) (%) | CDF 6 (54%) | CDF 8 (38%) | CDF 2 (40%) | 0.81 |
NED 3 (27%) | NED 6 (29%) | NED 1 (20%) | ||
AWD 1 (9%) | AWD 1 (5%) | AWD 1 (20%) | ||
DOD 1 (9%) | DOD 6 (29%) | DOD 1 (20%) | ||
Median period of bone union (mos.) (range) | 8 (4–15) | 8 (3–21) | 11 (7–15) | 0.47 |
Bone union rate within 1 year | 89% | 93% | 50% | 0.12 |
Functional score (MSTS score) (n) (%) | Excellent 8 (89%) Good 1 (11%) Fair 0 (0%) Poor 0 (0%) | Excellent 14 (78%) Good 3 (17%) Fair 1 (6%) Poor 0 (0%) | Excellent 5 (100%) | 1 |
5-year graft survival (%) | 64% | 83% | 75% | 0.64 |
Reasons for graft removal | ||||
Infection (n) (%) | 1 (9%) | 4 (19%) | 1 (20%) | 0.84 |
Fracture (n) (%) | 1 (9%) | 0 (0%) | 0 (0%) | 0.43 |
Non-union (n) (%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 |
Osteoarthritic change (n) (%) | 1 (9%) | 0 (0%) | 0 (0%) | 0.43 |
Recurrence (n) (%) | 2 (18%) | 2 (10%) | 1 (20%) | 0.51 |
Complications | ||||
Infection (n) (%) | 1 (9%) | 5 (24%) | 1 (20%) | 0.84 |
Fracture (n) (%) | 2 (18%) | 0 (0%) | 1 (20%) | 0.1 |
Non-union (n) (%) | 1 (9%) | 1 (5%) | 0 (0%) | 1 |
Limb deformity (n) (%) | 4 (36%) | 1 (5%) | 0 (0%) | 0.04 |
Osteoarthritic change (n) (%) | 2 (18%) | 2 (10%) | 0 (0%) | 078 |
Bone absorption (n) (%) | 0 (0%) | 2 (10%) | 1 (20%) | 0.23 |
Salvage amputation | ||||
Recurrence (n) (%) Infection (n) (%) | 1 (9%) 1 (9%) | 2 (10%) 3 (14%) | 1 (6%) 0 (0%) | 0.78 1.00 |
