Figure 1
From: Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity
Nnat deficient mice have a highly variable body weight phenotype. Body weight over time of Nnat+/+ and Nnat+/−p (A) male and (B) female mice on standard chow diet (at least 7 mice were included in each time point per genotype). Black arrow indicating time of the initiation of single housing. Mclust clustering showed significant variance of body weight at 12 weeks of age between Nnat+/+ and Nnat+/−p male (C) and females (D) mice (male; Nnat+/+ (n = 19), Nnat+/−p (n = 17): females; Nnat+/+ (n = 16), Nnat+/−p (n = 21)). (E) Body weight over time of Nnat+/+ and Nnat+/−p male mice fed 45% HFD (at least 7 mice at each time point per genotype). (F) Body weight over time of Nnat+/+ and Nnat+/−p male mice at thermoneutral condition (30 °C) fed on standard chow diet (at least 7 mice at each time point per genotype). Black arrow indicating time of the initiation of single housing. Data are expressed as mean (square-circle points) ± SD (dotted lines), *P < 0.05; **P < 0.01, 2-way ANOVA with multiple comparison.
