Figure 4

LOXL2 restored collagen II degradation in mandibular condyle cartilage at 4 and 7 d after force application. Immunohistochemical analysis of Collagen II expression and quantification of it in chondrocytes from samples treated as indicated (n = 12). (A) Degradation of collagen II in MF groups (4-days, p < 0.05; 7-days, p < 0.01; compared with the controls) was recovered by rhLOXL2(4-days, p < 0.05; 7-days, p < 0.01; compared with the MF groups), (B) while worsened by anti-LOXL2(4-days, p < 0.05; 7-days, p < 0.01; compared with the MF groups).