Figure 5
From: LOXL2 attenuates osteoarthritis through inactivating Integrin/FAK signaling
LOXL2 restored TNF-a over-expression in mandibular condyle cartilage at 4 and 7 d after force application. Immunohistochemical analysis of TNF-a expression and quantification of it in chondrocytes from samples treated as indicated at 4 or 7 d after force application (n = 12). (A) Degradation of TNF-a in MF groups (4-days, p < 0.05; 7-days, p < 0.01; compared with the controls) was recovered by rhLOXL2 (4-days, p < 0.05; 7-days, p < 0.01; compared with the MF groups), (B) while worsened by anti-LOXL2 (4-days, p < 0.05; 7-days, p < 0.01; compared with the MF groups).
