Table 1 Clinical and biochemical parameters in renal transplant patients receiving cyclosporine A (CsA) or tacrolimus (TAC) every 12 or 24 h.
Parameter | Drug | Mean ± SD | 95% CI | Minimum | Maximum | P |
|---|---|---|---|---|---|---|
Age (years) | CsA (12 h) | 53.69 ± 12.74 | 51.84–55.53 | 22 | 82 | |
TAC (12 h) | 47.10 ± 14.94 | 43.10–51.10 | 19 | 81 | ||
TAC (24 h) | 52.35 ± 12.81 | 50.40–54.30 | 19 | 81 | ||
Total | 52.24 ± 13.23 | 50.96–53.53 | 19 | 82 | ||
Weight (kg) | CsA (12 h) | 78.84 ± 17.16 | 76.35–81.33 | 40 | 139 | 0.083 |
TAC = 12 | 75.61 ± 15.77 | 71.38–79.83 | 44 | 132 | ||
TAC (24 h) | 75.13 ± 15.23 | 72.81–77.46 | 47 | 135 | ||
Total | 76.88 ± 16.27 | 75.30–78.46 | 40 | 139 | ||
BMI (kg/m2) | CsA (12 h) | 27.20 ± 5.11 | 26.46–27.94 | 17.31 | 42.9 | 0.075 |
TAC (12 h) | 25.72 ± 4.31 | 24.57–26.88 | 17.63 | 40.74 | ||
TAC (24 h) | 26.38 ± 4.41 | 25.71–27.06 | 18.59 | 43.58 | ||
Total | 26.66 ± 4.75 | 26.20–27.13 | 17.31 | 43.58 | ||
Sodium (mmol/L) | CsA (12 h) | 141.10 ± 3.54 | 140.59–141.62 | 120 | 149 | 0.078 |
TAC (12 h) | 140.71 ± 3.39 | 139.80–141.62 | 129 | 147 | ||
TAC (24 h) | 141.10 ± 2.89 | 140.66–141.55 | 132 | 149 | ||
Total | 141.05 ± 3.26 | 140.73–141.37 | 120 | 149 | ||
Potassium (mmol/L) | CsA (12 h) | 4.16 ± 0.44 | 4.10–4.23 | 3.14 | 5.42 | 0.451 |
TAC (12 h) | 4.20 ± 0.60 | 4.04–4.36 | 3.31 | 5.71 | ||
TAC (24 h) | 4.11 ± 0.47 | 4.04–4.19 | 2.93 | 6.09 | ||
Total | 4.15 ± 0.48 | 4.10–4.19 | 2.93 | 6.09 | ||
Bilirubin (mg/dL) | CsA (12 h) | 0.60 ± 0.28 | 0.56–0.64 | 0.16 | 1.69 | 0.002 |
TAC (12 h) | 0.50 ± 0.29 | 0.43–0.58 | 0.15 | 1.51 | ||
TAC (24 h) | 0.51 ± 0.24 | 0.47–0.54 | 0.15 | 1.58 | ||
Total | 0.55 ± 0.27 | 0.52–0.58 | 0.15 | 1.69 | ||
Urea nitrogen (mg/dL) | CsA (12 h) | 29.82 ± 12.95 | 27.94–31.70 | 8.3 | 71.1 | 0.201 |
TAC (12 h) | 27.74 ± 16.36 | 23.36–32.13 | 11.9 | 108.6 | ||
TAC (24 h) | 27.18 ± 14.60 | 24.95–29.41 | 7.5 | 111.9 | ||
Total | 28.46 ± 14.16 | 27.08–29.83 | 7.5 | 111.9 | ||
Creatinine (mg/dL) | CsA (12 h) | 1.60 ± 0.62 | 1.51–1.69 | 0.67 | 4.31 | 0.942 |
TAC (12 h) | 1.62 ± 0.68 | 1.44–1.80 | 0.73 | 3.52 | ||
TAC (24 h) | 1.59 ± 0.62 | 1.49–1.68 | 0.71 | 3.97 | ||
Total | 1.60 ± 0.63 | 1.54–1.66 | 0.67 | 4.31 | ||
eGFR | CsA (12 h) | 47.79 ± 15.18 | 45.6–49.99 | 14.22 | 75 | 0.863 |
TAC (12 h) | 49.09 ± 16.05 | 44.79–53.39 | 15.05 | 74 | ||
TAC (24 h) | 48.06 ± 16.12 | 45.59–50.52 | 14.4 | 75 | ||
Total | 48.08 ± 15.65 | 46.55–49.60 | 14.22 | 75 | ||
Uric acid (mg/dL) | CsA (12 h) | 6.95 ± 1.49 | 6.73–7.16 | 3.7 | 10.9 | 0.453 |
TAC (12 h) | 6.77 ± 1.60 | 6.34–7.20 | 4 | 10.8 | ||
TAC (24 h) | 6.76 ± 1.50 | 6.53–6.99 | 3.2 | 13.4 | ||
Total | 6.84 ± 1.51 | 6.70–6.99 | 3.2 | 13.4 | ||
ALT (U/L) | CsA (12 h) | 19.25 ± 10.94 | 17.67–20.84 | 3 | 73 | 0.258 |
TAC (12 h) | 21.14 ± 14.77 | 17.18–25.09 | 8 | 98 | ||
TAC (24 h) | 22.20 ± 22.23 | 18.82–25.59 | 5 | 206 | ||
Total | 20.72 ± 16.95 | 19.07–22.37 | 3 | 206 | ||
ASP (U/L) | CsA (12 h) | 20.68 ± 8.73 | 19.41–21.94 | 10 | 70 | 0.393 |
TAC (12 h) | 18.82 ± 7.37 | 16.84–20.79 | 9 | 55 | ||
TAC (24 h) | 21.07 ± 13.36 | 19.03–23.10 | 9 | 139 | ||
Total | 20.58 ± 10.73 | 19.54–21.62 | 9 | 139 | ||
Total cholesterol (mg/dL) | CsA (12 h) | 187.96 ± 39.37 | 182.15–193.77 | 80 | 344 | 0.437 |
TAC (12 h) | 183.11 ± 34.84 | 173.60–192.62 | 118 | 287 | ||
TAC (24 h) | 190.89 ± 40.80 | 184.65–197.12 | 119 | 409 | ||
Total | 188.53 ± 39.39 | 184.65–192.40 | 80 | 409 | ||
Cholesterol-HDL (mg/dL) | CsA (12 h) | 62.94 ± 20.48 | 59.29–66.58 | 27.6 | 118.8 | 0.265 |
TAC (12 h) | 57.01 ± 18.05 | 50.71–63.31 | 29 | 95 | ||
TAC (24 h) | 61.62 ± 16.82 | 58.49–64.76 | 20.6 | 104.4 | ||
Total | 61.64 ± 18.75 | 59.40–63.89 | 20.6 | 118.8 | ||
Cholesterol-LDL (mg/dL) | CsA (12 h) | 95.66 ± 35.84 | 89.26–102.06 | 36 | 239 | 0.232 |
TAC (12 h) | 96.35 ± 33.82 | 84.55–108.15 | 37 | 191 | ||
TAC (24 h) | 98.5 ± 31.39 | 92.62–104.37 | 27 | 188 | ||
Total | 96.93 ± 33.70 | 92.88–100.97 | 27 | 239 | ||
Triglycerides (mg/dL) | CsA (12 h) | 142.37 ± 65.41 | 130.75–154.00 | 48 | 404 | 0.545 |
TAC (12 h) | 152.61 ± 70.04 | 128.17–177.05 | 53 | 327 | ||
TAC (24 h) | 152.93 ± 91.75 | 135.83–170.04 | 55 | 839 | ||
Total | 148.06 ± 77.90 | 138.74–157.38 | 48 | 839 | ||
Total lipids (mg/dL) | CsA (12 h) | 638.50 ± 132.78 | 614.90–662.11 | 430 | 1183 | 0.598 |
TAC (12 h) | 641.35 ± 129.49 | 596.17–686.53 | 393 | 995 | ||
TAC (24 h) | 656.18 ± 143.83 | 629.37–682.99 | 409 | 1511 | ||
Total | 646.23 ± 136.88 | 629.86–662.60 | 393 | 1511 |
