Figure 2 | Scientific Reports

Figure 2

From: Comparative transcriptomic analysis of SARS-CoV-2 infected cell model systems reveals differential innate immune responses

Figure 2

The transcriptome of SARS-CoV-2 infection in HEK293T-hACE2 cells. (a) Volcano Plot of DEGs of SARS-CoV-2 infection in HEK293T-hACE2 cells. (b) Volcano Plot of DEGs of SARS-CoV-2 infection in A549-hACE2 cells. (c) Percentage of reads mapped to SARS-COV-2 genome and human hg38 genome from the nine RNAseq datasets of SARS-COV-2 infection in cell lines used in this study. (d) Major KEGG pathways enriched with DEGs of SARS-CoV-2 infection in HEK293T-hACE2. (e) Major KEGG pathways enriched with DEGs of SARS-CoV-2 infection in A549-hACE2. (f) Heatmap of SARS-CoV-2 gene expression SARS-CoV-2 infected cells by transcripts per million (TMP). HEK293T_A and A549_A represent HEK293T or A549 with hACE2 overexpression, respectively. Calu3_B and Calu3_C represent data from the RNAseq data by Wyler E. (bioRxiv) and Blanco-Melo D. (Cell), respectively.

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