Table 2 Incidences of outcomes in the Study Cohort.

From: Association of proteinuria and incident atrial fibrillation in patients with diabetes mellitus: a population-based senior cohort study

Group

Total patient, n

Event, n

Crude incidence

per 100 patient-years

Weighted incidence

per 100 patient-years

Absolute reduction in event rate (95% CI)

Weighted hazard ratio

(95% CI)*

P for trend

Atrial fibrillation

      

 < 0.001

DM-Prot-

202,291

7426

0.58

0.60

 

1.00 (reference)

 

DM + Prot-

31,088

1269

0.70

0.65

0.12 (0.16–0.08)

1.11 (1.02–1.20)

 

DM-Prot + 

4953

271

0.96

0.88

0.38 (0.49–0.27)

1.48 (1.30–1.69)

 

DM + Prot + 

2167

141

1.24

1.00

0.66 (0.87–0.46)

1.66 (1.26–2.18)

 

Stroke

      

 < 0.001

DM-Prot-

202,291

9881

0.78

0.79

 

1.00 (reference)

 

DM + Prot-

31,088

2277

1.27

1.29

0.69 (0.74–0.64)

1.67 (1.57–1.77)

 

DM-Prot + 

4953

303

1.08

0.99

0.49 (0.62–0.37)

1.31 (1.16–1.48)

 

DM + Prot + 

2167

254

2.30

2.36

1.72 (2.00–1.44)

3.02 (2.48–3.68)

 

Heart failure hospitalization

      

 < 0.001

DM-Prot-

202,291

3369

0.26

0.27

 

1.00 (reference)

 

DM + Prot-

31,088

689

0.38

0.35

0.11 (0.14–0.08)

1.28 (1.15–1.43)

 

DM-Prot + 

4953

160

0.56

0.46

0.30 (0.38–0.21)

1.73 (1.45–2.06)

 

DM + Prot + 

2167

95

0.83

0.69

0.57 (0.73–0.40)

2.59 (1.93–3.46)

 

Cardiovascular death

      

 < 0.001

DM-Prot-

202,291

4458

0.34

0.35

 

1.00 (reference)

 

DM + Prot-

31,088

815

0.44

0.46

0.10 (0.13–0.06)

1.40 (1.27–1.54)

 

DM-Prot + 

4953

193

0.67

0.54

0.32 (0.42–0.23)

1.57 (1.34–1.84)

 

DM + Prot + 

2167

102

0.87

0.77

0.53 (0.70–0.36)

2.44 (1.80–3.32)

 
  1. *After inverse probability of treatment weighting.
  2. Covariates adjusted for age, sex, BMI, smoking, alcohol, hypertension, dyslipidemia, chronic kidney disease, myocardial infarction, chronic obstructive pulmonary disease, osteoporosis, liver disease, and malignancy.
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