Figure 2 | Scientific Reports

Figure 2

From: The retinoid X receptor α modulator K-80003 suppresses inflammatory and catabolic responses in a rat model of osteoarthritis

Figure 2

K-80003 regulates synovitis in OA rats. SD rats were injected intra-articularly (i.a.) with saline or MIA (1 mg, 20 μL) through the infrapatellar ligament of the hind knees, and were i.a. injected with vehicle or K-80003 (1 or 2 mg/kg, 20 μL) at days 7, 10, 14, 17, 21, 24 after MIA treatment. All animals were sacrificed 28 days after MIA injection, and synovium were dissected for ELISA and histopathological studies. (A) H&E staining of synovial membranes of animals at week 2 and 4. Synovium were measured by the synovitis score. (B) Immunofluorescence analyses and quantification of F4/80 in the tibia medial compartment of animals. (C–E) The concentrations of IL-6, IL-1β and TNF-α in homogenates of synovial membranes were measured by ELISA. *P < 0.05; **P < 0.01; ***P < 0.001; n = 8.

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