Figure 3 | Scientific Reports

Figure 3

From: The retinoid X receptor α modulator K-80003 suppresses inflammatory and catabolic responses in a rat model of osteoarthritis

Figure 3

The analgesic effects of K-80003 on allodynia in OA rats. SD rats were injected intra-articularly (i.a.) with saline or MIA (1 mg, 20 μL) through the infrapatellar ligament of the hind knees, and were i.a. injected with vehicle or K-80003 (1 or 2 mg/kg) at days 7, 10, 14, 17, 21, 24 after MIA treatment. Tactile allodynia was tested on the hind paw in OA and sham rats at day 8, 15, 22 and 28, and measured the paw withdrawal threshold (PWT) values. *P < 0.05; **P < 0.01; ***P < 0.001; n = 8.

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