Table 1 Comparison results of connectivity score using LINCS L1000 dataset.
Cell line | Perturbagen ID | Drug name | Zhang score | Targets | ||
|---|---|---|---|---|---|---|
Gene symbol | UniProt ID | Name of target proteins* | ||||
A375 | BRD-K15933101 | Ropinirole | 0.152284551 | |||
BRD-K40758068 | Efavirenz | 0.14029383 | ||||
BRD-K70505054 | Ranitidine | 0.127356285 | HRH2 | P25021 | Histamine H2 receptor | |
A549 | BRD-A64290322 | Cyclosporine | 0.151246937 | PPP3R2, PPIA | Q96LZ3, P62937 | Calcineurin subunit B type 2, Peptidyl-prolyl cis–trans isomerase A |
BRD-A79768653 | Sirolimus | 0.113739203 | MTOR | P42345 | Serine/threonine-protein kinase mTOR | |
BRD-K84937637 | Sirolimus | 0.111655751 | MTOR | P42345 | Serine/threonine-protein kinase mTOR | |
MCF7 | BRD-A22032524 | Amlodipine | 0.19968588 | CACNA1C, CACNA1I | Q13936, Q9P0X4 | Voltage-dependent L-type calcium channel subunit alpha-1C, Voltage-dependent T-type calcium channel subunit alpha-1I |
BRD-A01320529 | Salmeterol | 0.194945701 | ||||
BRD-K91263825 | Nortriptyline | 0.182943722 | SLC6A2, SLC6A4, HTR2A | P23975, P31645, P28223 | Sodium-dependent noradrenaline transporter, Sodium-dependent serotonin transporter, 5-hydroxytryptamine receptor 2A | |
PC3 | BRD-K89732114 | Trifluoperazine | 0.158636237 | DRD2, CALY, ADRA1A | P14416, 9NYX4, P35348 | Dopamine D2 receptor, Neuron-specific vesicular protein calcyon, Alpha-1A adrenergic receptor |
BRD-A45889380 | Quinacrine | 0.155439425 | PLA2G6, PLA2G4A, PLCL1 | O60733, P47712, Q15111 | 85/88 kDa calcium-independent phospholipase A2, Cytosolic phospholipase A2, Inactive phospholipase C-like protein 1 | |
BRD-A29485665 | Bicalutamide | 0.131271152 | AR | P10275 | Androgen receptor | |
