Table 4 Acute procedural results. Global and per vein application analysis.

Per vein analysis	LSPV ^A	LIPV^B	RSPV^C	RIPV^D
Total veins (n)	1537	1534	1691	1660
Total applications (n)	2828	2766	3059	3148
Applications per vein	1.8 ± 1.07	1.8 ± 1.01	1.8 ± 1.06	1.9 ± 1.17
Time per application (s)	179.7 ± 56.14^BD	179.7 ± 59.74^AD	173.6 ± 58.76*	179.4 ± 57.65^AB
PV potentials (%)	1110 (72.4)*	967 (63.2) *	997 (59.2) *	834 (50.6) *
TTE (s)	52.1 ± 34.14^BC	51 ± 34.3^AC	49.0 ± 38.88^AB	59.0 ± 39.62*
Temperature at PVI (°C)	− 35.2 ± 9.29^D	− 31.3 ± 9.7*	− 33.2 ± 10.78^D	− 34.4 ± 9.43^C
PVI with 1st application; n (%)	1487 (77.67)^BCD	1455 (78.35)^AC	1610 (75.0)^ABD	1552 (73.7)^AD
Total cryotherapy time (s)	330.3 ± 173.92^BCD	323.8 ± 162.16^AC	314.0 ± 174.86^AB	340.4 ± 193.07^A
Minimum temperature (°C)	− 46.4 ± 8.04*	− 43.4 ± 7.84*	− 47.3 ± 8.07*	− 44.4 ± 8.20*
Rewarming time (s)	43.3 ± 22.82*	36.7 ± 18.94^D	41.0 ± 19.63*	34.3 ± 17.80^B

Differences on averages by patient-location, since multiple applications could have received at each patient-location (on average 1.8 applications over each location) are shown, using a mixed-effects model and adjusting for multiple comparisons (Bonferroni). Locations with a significantly different value (p < 0.001) differing from all other locations are flagged with an asterisk. When the average compared is not different from another location (p > 0.05), the value is labeled with a letter corresponding to the non-significant locations (labeled from left to right: A, B, C, D).
Quantitative data are the mean ± standard deviation.
PV pulmonary vein, PVI PV isolation, TTE time to effect, LSPV left superior pulmonary vein, LIPV left inferior pulmonary vein, RSPV right superior pulmonary vein, RIPV right inferior pulmonary vein.

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