Figure 6
From: LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1
Effects of LSD and MDL100907 on prepulse inhibition in β-arrestin 2 mice. A description of the experimental design is provided in the Fig. 5 legend. PPI in WT and βArr2-KO mice treated with MDL or LSD. A RMANOVA found the main effects of prepulse intensity [F(1,74) = 580.044, p < 0.001], genotype [F(1,74) = 18.823, p < 0.001], and treatment [F(4,74) = 3.953, p = 0.006] to be significant; the genotype by treatment interaction [F(4,74) = 5.660, p < 0.001] was also significant. N = 8–10 mice/group. ***p < 0.05, WT vs. KO; +++p < 0.001, LSD vs. indicated groups within genotype; ^p < 0.05, 0.05MDL + LSD versus indicated groups within genotype.
