Figure 7
From: LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1
Radioligand binding and immunohistochemistry of 5-HT2ARs in βArr1 and βArr2 mice. (a) Competition binding with [3H]-ketanserin using membranes from βArr1 and βArr2 brains. The Kd values for binding were 21.3, 26.8, 40.8, and 38.7 nM from WT and βArr1-KO, and WT and βArr2-KO mice, respectively. N = 3 mice/genotype. (b-e) Representative 5-HT2AR immunofluorescence in coronal brain sections from respective WT and βArr1-KO mice (top), and WT and βArr2-KO (bottom) animals.
