Table 2 Left ventricular morphological and functional parameters assessed by transthoracic echocardiography at week 12 and blood pressure values at week 13.

HR (1/min)

361 ± 9

386 ± 9

383 ± 13

332 ± 4^#

LVEDV (μl)

275 ± 12

262 ± 19

262 ± 17

368 ± 33*^#

LVESV (μl)

124 ± 8

120 ± 10

107 ± 11

181 ± 26*^#

SV (μl)

152 ± 11

142 ± 10

161 ± 9

181 ± 8^#

CO (mL/min)

55 ± 4

55 ± 4

61 ± 4

60 ± 3

IVCT (ms)

13.3 ± 0.67

10.8 ± 0.59*

12.22 ± 0.66

14.43 ± 0.61^#

IVRT (ms)

14.3 ± 0.72

11.7 ± 0.47*

12.78 ± 0.43

14.71 ± 1.15^#

E-velocity (m/s)

0.97 ± 0.03

1.02 ± 0.05

1.06 ± 0.04

1.06 ± 0.06

E/e’

19.45 ± 1.28

28.21 ± 2.66*

22.82 ± 1.55

22.88 ± 1.39

AWTs (mm)

3.19 ± 0.1

3.65 ± 0.09*

3.41 ± 0.05

3.56 ± 0.1*

AWTd (mm)

1.96 ± 0.03

2.17 ± 0.04*

1.98 ± 0.04^#

2.24 ± 0.11*

IWTs (mm)

3.01 ± 0.11

3.69 ± 0.1*

3.32 ± 0.13

3.51 ± 0.29

IWTd (mm)

1.82 ± 0.06

2.18 ± 0.05*

1.92 ± 0.06^#

1.99 ± 0.19

SBP (mmHg)

145 ± 4

166 ± 13

142 ± 4

170 ± 9

DBP (mmHg)

104 ± 2

122 ± 10

102 ± 3

127 ± 6

MBP (mmHg)

119 ± 3

139 ± 11

117 ± 3

144 ± 8